In order to investigate the antidiabetogenic activity of T. kirilowii on the alloxan-treated mice, the effects of the oral administration of the methanol extract on the blood glucose, the survival rate and the histological changes of the Langerhans¡¯¡¯ islet were observed. The blood glucose was reached at the highest levels of 265.03 +/- 15.07 and 186.41 +/- 10.16mg/dl at 30 min after alloxan injection, and at the lowest levels of 43.35 +/- 5.28 at 4 hour and 20.40 +/- 3.26mg/dl at 10 hour in experimental and control group, respectively. 57.15% of the experimental group and 4.2% of the control group were survived more than 24 hours. The life spans of the mice, which were dead within 24 hours, were 631.45 +/- 60.17 for the experimental group and 414.60 +/- 36.24 min for the control group. The mice from the control group, which were dead within 10 hours, showed totally necrotized alpha- and beta-cells. However, 3 of the 10 mice from the experimental group, which were survived until 24 hours, showed a normal histological feature of the Langerhans¡¯ islet.
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